Our ultimate goal is that oncologists become able to design custom peptide vaccines in minutes.This web service illustrates this vision. When filled in with relevant information, it is able to design multiple peptides with different profiles (better fit for a given HLA, most immunogenicity, etc.).
This Proof-Of-Concept is obviously a work in progress that does not pretend to have any medical value.
There are many economic and medical roadblocks in the process leading to market authorization.
If oncologists (or their health providers) were able to define vaccines in either the off label use, compassionate or expanded access legal frameworks, lot of people would be helped.
We are focusing here on peptide vaccines because while most of the clinical results using peptide vaccines have been disappointing, a peptide vaccine with
appropriate adjuvants is easy to produce, low cost and probably one of the easiest strategies to induce tumor-responsive T cells in people who are still in good health.
But indeed peptide vaccines can be dangerous too.
Only an oncologist can make sense of what is pertinent for a given patient.
Economically, peptide vaccines make sense, as a few dozen doses of peptides are worth only $500.
Here is a FAQ
The source code is available here.