A valuable Old Timer

General Electric’s BiodMet is a Java PBPK simulator which is quite old now. It appears in 2008 and did not receive any improvements  at least since 2013. Indeed there are ferocious competitors like Certara’s SimCyp and many others.

However it is still an impressive software, with a GUI providing a detailed simulation of many organs seemingly up to cell level. Indeed not everything is perfect, there is nothing about eyes, the circulatory system is very basic, there is only one lung or kidney, genital organs simulation is not implemented, but for a free to use software it is nevertheless awesome. When the software runs a simulation it says it uses 2126 ODEs equation, which is extremely impressive.

In order to test the veracity of this claim, we used the same approach as in last post. It turns out this claim is somehow true.

Actually the body itself is simulated with 52 equations (mostly for modeling blood usage by organs at cell level and modeling a few to model inter-organ fluid exchanges). There are also for each organ a set of 82 ODEs to model how the drug moves from one compartment to the next and how it is transformed. The pattern is to model how the drug moves from vasculature to organs interstitial medium, and from there back to  vasculature and to cell’s cytosol and from there to each compartment of the cell.

BiodMet is still available at: http://pdsl.research.ge.com/

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