In recent years, the role of lactate metabolism and its derived lactylation modifications in Alzheimer's disease has received increasing attention. Studies have shown that in the brains of Alzheimer's disease patients, glucose metabolism is significantly reduced, while glycolysis is upregulated, and lactate levels are elevated. Nevertheless, the research regarding the relationship between lactylation and Alzheimer's disease remains limited. Building on recent advances in understanding lactylation in neurodegenerative diseases and related conditions, the authors analyze and explore the potential relationships between lactylation and Alzheimer's disease from the perspectives of -amyloid deposition, tau protein pathology, and neuroinflammation. In summary, lactylation, as a novel post-translational modification holds significant promise in elucidating the pathological mechanisms and advancing the treatment of Alzheimer's disease. A deeper investigation into its molecular mechanisms and regulatory networks may open new avenues for the diagnosis and treatment of Alzheimer's disease.
