Reproductive aging, including timing of menarche and menopause, influences long-term morbidity and mortality in women, yet underlying biological mechanisms remain poorly understood. Using DNA methylation-based biomarkers, the authors assessed associations of age at menarche and menopause with epigenetic aging in a nationally representative sample of women 50 years. Later age at menopause was associated with lower GrimAge epigenetic age deviation. No associations were observed for menarche timing. This suggests a connection between earlier menopause and biological aging, with potential clinical implications for identifying those at high risk for age-related disease.
