Design and Analysis of N-Of-1 Trials That Incorporate Sequential Monitoring.

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The scientists here propose novel designs for both the single-person and multi-person N-of-1 trials that employ sequential monitoring. In particular, the authors allow for early stopping for a single participant as soon as there is sufficient evidence of a preferred treatment for them, and early stopping for the group of participants as soon as there is sufficient evidence of a preferred treatment for the population of patients.

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