Cerebral small vessel disease often coexists with neurodegenerative pathologies, yet their role remains underexplored. This study aims to determine their prevalence, risk factors, and cognitive effects in patients with deep perforator arteriopathy or cerebral amyloid angiopathy using the biomarker-based ATN classification.
The COVID-19 pandemic represented a healthcare challenge of unparalleled magnitude worldwide. As patients recovered from the acute infection, a new challenge emerged, i.e., the development of post-acute symptoms. The main goal of this study was to evaluate the trajectory of cognitive symptoms since the acute phase of COVID-19 among patients followed through a telehealth program in Brazil.
This study examines the incidence, prevalence, deaths, and disability-adjusted life years related to non-communicable diseases in South Asia, exploring the environmental, metabolic, and behavioural risk factors, and exploring changes in deaths and DALYs driven by population growth, aging, and mortality rates.
The scientists here compared the synaptic plasticity actions of two relatively standard preparations of soluble recombinant tau assemblies, fibril-derived soluble sonicated tau aggregates and oligomer-enriched tau prepared from monomers. To test the role of pro-inflammatory cytokines in mediating the disruptive effects of the two forms of soluble tau on synaptic plasticity the authors pre-injected etanercept, a decoy receptor for tumor necrosis factor alpha. Moreover, injection of exogenous TNF mimicked the facilitation of LTD by oTau, consistent with a role of this pro-inflammatory cytokine in LTD facilitation.These data provide evidence that preparations of soluble tau containing either monomer- or fibril-derived assemblies disrupt LTP and LTD via different mechanisms.