The abnormal accumulation of pathological proteins and compensatory functional connectivity enhancement of insula subdivisions in mild cognitive impairment.

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The insula is a critical node of the salience network responsible for initiating network switching, and its dysfunctional connections are linked to the mechanisms of mild cognitive impairment. This study aimed to explore the changes in functional connectivity of insular subregions in MCI patients with varying levels of cerebrospinal fluid pathological proteins, and to investigate the impact of these proteins on the brain network alterations in MCI.

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