SERCA-mediated endoplasmic reticulum stress facilitates hematopoietic stem cell mobilization.

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Hematopoietic stem cell transplantation is widely recognized as an effective treatment for various malignant diseases. Enhancing HSC mobilization can improve transplantation outcomes and ultimately increase patient survival rates. Recent studies suggest that mild endoplasmic reticulum stress promotes HSC self-renewal, anti-apoptotic, and anti-aging capabilities. This led them to investigate whether inducing mild ER stress could facilitate HSC mobilization.

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