Objectives: Dementia of the Alzheimer's type (DAT) is the most common chronic neurodegenerative disease. At present, the pathogenesis of Alzheimer's disease is not completely clear, and there are no drugs that can cure the disease. Once an individual is diagnosed with Alzheimer's disease, the survival time is only 3 to 9 years.
Therefore, there is an urgent need to determine the etiology of Alzheimer's disease and the associated influencing factors to find a breakthrough in the treatment of DAT.
Methods: We studied the relationship between polymorphisms in several genes (including BIN1 and APOE) and Alzheimer's disease susceptibility and the effects of sex differences on Alzheimer's disease.
Our study included 137 patients with Alzheimer's disease and 509 healthy controls (HCs). Results: The APOE rs429358 polymorphism CC and CT genotypes were associated with an increased risk of Alzheimer's disease in women.
We found a significant association between APOE ε4 and Alzheimer's disease. The frequency of the ε4 allele in the Alzheimer's disease group (15.5%) was higher than that in the HC group (8.7%). The BIN1 rs7561528 polymorphism was associated with a decreased risk of DAT in men.
Conclusions: APOE gene rs429358 and BIN1 gene 7561528 genes may affect the susceptibility to Alzheimer's disease in a Chinese Han population.