Chronic kidney disease is increasingly prevalent among the elderly, yet current diagnostic criteria often fail to distinguish between true CKD and age-related physiological decline in glomerular filtration rate. This overestimation can lead to overdiagnosis, overtreatment, and psychological distress. Frailty, a common condition in older adults, further complicates the clinical picture. This study aimed to reclassify CKD in the elderly by integrating age-adjusted GFR estimation and frailty assessment in a regional Italian population.
