In patients with Parkinson's disease, it is believed since the work of Heiko Braak, that α-synuclein pathology spreads to the brain via the vagus nerve. The link between gut microbiota and Parkinson's disease has been explored in various studies. One clue is that patients are often constipated.
Recently, appendectomy has been associated with a lower risk of Parkinson's disease, possibly due to the appendix's role in altering the gut microbiome. However, the faecal microbiota in patients without a history of appendectomy may show considerable interindividual variation which makes any conclusion difficult.
The authors of a new paper published in Nature/Scientific reports, sought to elucidate whether gut microbiota affects the development of Parkinson's disease in an appendectomy cohort.
The Japanese scientists analyzed the fecal microbial composition in about twenty patients with Parkinson's disease and healthy controls with and without a history of appendectomy. 10 subjects had Parkinson's disease, while 10 others constituted the control group. Each of these two groups was subdivided into two groups of 5 subjects, one for subjects who had not undergone appendectomy, the other group consisting of those who had undergone this operation.
The abundance of microbes from the Enterobacteriaceae family was higher in fecal matter samples from patients with Parkinson's disease than in samples taken from healthy controls. It should be noted that Enterobacteriaceae, such as Escherichia coli and Salmonella, produce bacterial amyloids called curli. Therefore, Enterobacteriaceae can induce PD α-synuclein pathology.
Microbes from the Proteobacteria, Gammaproteobacteria, Enterobacteriales, and Enterobacteriaceae groups were more enriched in PD patients than in healthy controls. The scientists found that the genus Serratia, of the order Enterobacteriales, had a higher abundance in fecal samples from patients with PD than from healthy controls.
Serratia was thought to be a harmless environmental bacterium until the most common species of the genus, S. marcescens, was discovered to be an opportunistic pathogen. In humans, S. marcescens is primarily associated with nosocomial or nosocomial infections, but can also cause urinary tract infections, pneumonia, and endocarditis. S. marcescens is frequently found in showers, toilet bowls, and around wet tiles as a pinkish to red biofilm.
Some studies have demonstrated that the gut microbiota of patients with PD has a low abundance of Prevotella, while other studies have shown conflicting results. It is possible that the abundance of Prevotellaceae in the gut microbiota may be correlated with the severity of constipation, and not with PD.
Individuals in the healthy group had the highest body mass indices. A reduction in the Firmicutes/Bacteroidetes ratio in patients with PD was observed between the PD and control groups in a previous study.
Moreover, there was a significant phylogenetic difference between patients with Parkinson's disease and healthy controls who had undergone appendectomy. There was a significant phylogenetic difference between patients with Parkinson's disease and healthy controls who had undergone appendectomy. These results suggest the correlation between gut microbiota and Parkinson's disease in patients who have undergone appendectomy.