Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model

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Scientists from Korea and Germany, shown that human fibroblasts can be converted into induced motor neurons (iMNs) by sequentially inducing POU5F1(OCT4) and LHX3. This is a radical simplification in the process to induce fibroblasts in morphing into motor neurons. Fibroblasts are a common cell type found in conjonctive tissue. In addition the scientists transplanted those iMNs in a rodent spinal cord injury model. The iMNs promoted locomotor functional recovery.

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